Format

Send to

Choose Destination
See comment in PubMed Commons below
Oncol Nurs Forum. 2009 Mar;36(2):225-31. doi: 10.1188/09.ONF.225-231.

Management of temozolomide toxicity by nurse practitioners in neuro-oncology.

Author information

1
Department of Neurology, Medical Centre Haaglanden, Netherlands. h.zwinkels@mchaaglanden.nl

Abstract

PURPOSE/OBJECTIVES:

To investigate the toxicity of temozolomide (TMZ) in patients with brain tumors and appropriate nursing interventions.

DESIGN:

Explorative analysis of prospective data.

SETTING:

A TMZ clinic led by a nurse practitioner (NP).

SAMPLE:

Group A (n = 71) received a standard dose of TMZ daily for five days 200 mg/m2 every four weeks; group B (n = 19) received a dose-intense schedule of TMZ daily for 21 days 75 mg/m2 every four weeks.

METHODS:

Toxicities were scored according to National Cancer Institute Common Terminology Criteria, and results in the two groups were compared.

MAIN RESEARCH VARIABLES:

Thrombopenia, neutropenia, and lymphopenia; nausea and vomiting; and NP interventions.

FINDINGS:

Of observed toxicities during six cycles, grade 3-4 thrombopenia was seen most frequently in group A. Neutropenia and subsequent interventions occurred more frequently in group A than in group B. Subsequent interventions consisted of dose delays and reductions. When patients were treated for a longer duration of time with TMZ, grade 3-4 lymphopenia occurred significantly more often in group B, necessitating Pneumocystis carinii pneumonia prophylaxis.

CONCLUSIONS:

Degree of toxicity using a 5-day 200 mg/m2 or 21-day 75 mg/m2 schedule every four weeks was similar to that found in other studies.

IMPLICATIONS FOR NURSING:

Through awareness of toxicity in relation to knowledge of brain tumors, NPs can become more effective in active management of TMZ toxicity.

PMID:
19273412
DOI:
10.1188/09.ONF.225-231
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Oncology Nursing Society
    Loading ...
    Support Center