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Front Biosci (Landmark Ed). 2009 Jan 1;14:2004-16.

Differential calcium signalling in neuronal-glial networks.

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  • 1Institute of Experimental Medicine, ASCR, Videnska 1083, 142 20 Prague 4, Czech Republic.


Calcium ions are the probably the most ancient, the most universal and omnipresent intracellular signalling molecules, which are involved in regulation of a host of cellular functional reactions. In the nervous system Ca2+ signalling is intimately involved in information transfer and integration within neural circuits. Local Ca2+ signals or Ca2+ microdomains control neurotransmitter release; more global Ca2+ signals regulate synaptic strength and accomplish postsynaptic processing. In the glial syncytium Ca2+ ions provide for glial "Ca2+ excitability", convey long-range signalling by means of propagating Ca2+ waves and control the release of gliotransmitters. Differential Ca2+ signals in various elements of neural circuits represent therefore molecular mechanisms of integration in the nervous system.

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