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Front Biosci (Landmark Ed). 2009 Jan 1;14:2004-16.

Differential calcium signalling in neuronal-glial networks.

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  • 1Institute of Experimental Medicine, ASCR, Videnska 1083, 142 20 Prague 4, Czech Republic. alex.verkhratsky@manchester.ac.uk

Abstract

Calcium ions are the probably the most ancient, the most universal and omnipresent intracellular signalling molecules, which are involved in regulation of a host of cellular functional reactions. In the nervous system Ca2+ signalling is intimately involved in information transfer and integration within neural circuits. Local Ca2+ signals or Ca2+ microdomains control neurotransmitter release; more global Ca2+ signals regulate synaptic strength and accomplish postsynaptic processing. In the glial syncytium Ca2+ ions provide for glial "Ca2+ excitability", convey long-range signalling by means of propagating Ca2+ waves and control the release of gliotransmitters. Differential Ca2+ signals in various elements of neural circuits represent therefore molecular mechanisms of integration in the nervous system.

PMID:
19273181
[PubMed - indexed for MEDLINE]
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