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J Org Chem. 2009 Apr 3;74(7):2736-42. doi: 10.1021/jo900008w.

Antimalarial bromophycolides J-Q from the Fijian red alga Callophycus serratus.

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1
School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.

Abstract

Bromophycolides J-Q (1-8) were isolated from extracts of the Fijian red alga Callophycus serratus and identified with 1D and 2D NMR spectroscopy and mass spectral analyses. These diterpene-benzoate macrolides represent two novel carbon skeletons and add to the 10 previously reported bromophycolides (9-18) from this alga. Among these 18 bromophycolides, several exhibited activities in the low micromolar range against the human malaria parasite Plasmodium falciparum.

PMID:
19271727
PMCID:
PMC2707147
DOI:
10.1021/jo900008w
[Indexed for MEDLINE]
Free PMC Article

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