Format

Send to

Choose Destination
See comment in PubMed Commons below
Eur J Pediatr. 2009 Aug;168(8):891-6. doi: 10.1007/s00431-009-0955-7. Epub 2009 Mar 7.

Clinical practice. Diagnosis and treatment of cow's milk allergy.

Author information

  • 1Department of Paediatrics, VU University Medical Centre, Amsterdam, The Netherlands. cmf.kneepkens@vumc.nl

Abstract

INTRODUCTION:

Cow's milk allergy (CMA) is thought to affect 2-3% of infants. The signs and symptoms are nonspecific and may be difficult to objectify, and as the diagnosis requires cow's milk elimination followed by challenge, often, children are considered cow's milk allergic without proven diagnosis.

DIAGNOSIS:

Because of the consequences, a correct diagnosis of CMA is pivotal. Open challenges tend to overestimate the number of children with CMA. The only reliable way to diagnose CMA is by double-blind, placebo-controlled challenge (DBPCFC).

THERAPY:

At present, the only proven treatment consists of elimination of cow's milk protein from the child's diet and the introduction of formulas based on extensively hydrolysed whey protein or casein; amino acid-based formula is rarely indicated. The majority of children will regain tolerance to cow's milk within the first 5 years of life.

CONCLUSIONS:

Open challenges can be used to reject CMA, but for adequate diagnosis, DBPCFC is mandatory. In most children, CMA can be adequately treated with extensively hydrolysed whey protein or casein formulas.

PMID:
19271238
PMCID:
PMC2694929
DOI:
10.1007/s00431-009-0955-7
[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer Icon for PubMed Central
    Loading ...
    Support Center