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Cell Adh Migr. 2009 Apr-Jun;3(2):205-10. Epub 2009 Apr 16.

Cell lineages and early patterns of embryonic CNS vascularization.

Author information

1
Paracelsus Private Medical University Salzburg, Austria. haymo.kurz@pmu.ac.at

Abstract

First steps of blood vessel formation and patterning in the central nervous system (CNS) of higher vertebrates are presented. Corresponding to the regional diversity of the embryonic CNS (unsegmented spinal cord vs segmented brain anlagen) and its surroundings (segmented trunk vs unsegmented head mesoderm, neural crest-derived mesenchyme), cells of different origins contribute to the endothelial and mural cell populations. The autonomous migratory potential of endothelial cells is guided by attractive and repulsive clues. Nevertheless, a common pattern in both spinal cord and forebrain vascularization appears, with primary ventral vascular sprouts supplying the periventricular vascular plexus of the neural tube, whereas dorsolateral sprouts appear later.

PMID:
19270493
PMCID:
PMC2679888
DOI:
10.4161/cam.3.2.7855
[Indexed for MEDLINE]
Free PMC Article

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