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Biosci Biotechnol Biochem. 2009 Mar 23;73(3):489-93. Epub 2009 Mar 7.

Fermented barley extract suppresses the development of atopic dermatitis-like skin lesions in NC/Nga mice, probably by inhibiting inflammatory cytokines.

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1
YAEGAKI Bio-Industry, Inc., Himeji, Hyogo, Japan. iguch-tk@yaegaki.co.jp

Abstract

We have found that fermented barley extract (FBE), prepared from barley shochu residue, alleviates allergic rhinitis in OVA-sensitized mice. In this study, we examined to determine whether FBE suppresses the development of atopic dermatitis (AD)-like skin lesions in NC/Nga mice. The development of AD-like skin lesions in a 5% FBE containing diet group was significantly inhibited, and scratching behavior, one of aggravating factors, was also suppressed. Neither serum immunoglobulin E (IgE) levels nor interleukin (IL)-4 production by spleen cells in the 5% FBE diet group was found to be significantly reduced. On the other hand, interferon-gamma (IFN-gamma) and IL-17 production by spleen cells in the 5% FBE diet group was significantly reduced. Hence it was assumed that FBE alleviates AD-like skin lesions in NC/Nga mice, probably by modulating the cytokine production involved in chronic inflammation, such as IFN-gamma or IL-17.

PMID:
19270394
[Indexed for MEDLINE]
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