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Vet Microbiol. 2009 Jun 12;137(3-4):408-11. doi: 10.1016/j.vetmic.2009.01.036. Epub 2009 Jan 31.

In vitro activity of terbinafine associated to amphotericin B, fluvastatin, rifampicin, metronidazole and ibuprofen against Pythium insidiosum.

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1
Departamento de Microbiologia e Parasitologia, Laboratório de Pesquisas Micológicas (LAPEMI), Universidade Federal de Santa Maria (UFSM), Avenida Roraima, 1000, Cidade Universitária, Bairro Camobi, Santa Maria-RS, 97105-900, Brazil.

Abstract

We evaluated the in vitro activities of terbinafine alone and in combination with amphotericin B, fluvastatin, rifampicin, metronidazole or ibuprofen against 17 clinical isolates of Pythium insidiosum. The assays were based on technique M38-A2, as well as the checkerboard microdilution method. The main synergism observed was by combination of terbinafine plus amphotericin B (41.18%). Antagonisms were observed in combinations of terbinafine with fluvastatin (35.30%) or rifampicin (5.88%).

PMID:
19269752
DOI:
10.1016/j.vetmic.2009.01.036
[Indexed for MEDLINE]
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