Treatment planning for adult oral rehabilitation starts before cases are scheduled and continues after the discharge phase. Practitioners providing dental care must be competent in all phases of dentistry and comfortable in the operating room setting. Dental caries risk assessment and medical risk assessment are important in developing comprehensive and predictable treatment plans. Oral rehabilitation in the operating room for patients who have special needs is a growing concern. Coordinating medical procedures with oral rehabilitation procedures while patients are under general anesthetic is an efficient use of sedation. A systematic approach for treatment plan consideration is explored for oral rehabilitation cases using general anesthesia or monitored anesthesia care.