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FEBS Lett. 2009 Jun 5;583(11):1759-65. doi: 10.1016/j.febslet.2009.03.001. Epub 2009 Mar 6.

A network medicine approach to human disease.

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Institute for Research in Biomedicine and Barcelona Supercomputing Center, c/ Baldiri i Reixac 10-12, 08028 Barcelona, Spain.


High-throughput interaction discovery initiatives are providing thousands of novel protein interactions which are unveiling many unexpected links between apparently unrelated biological processes. In particular, analyses of the first draft human interactomes highlight a strong association between protein network connectivity and disease. Indeed, recent exciting studies have exploited the information contained within protein networks to disclose some of the molecular mechanisms underlying complex pathological processes. These findings suggest that both protein-protein interactions and the networks themselves could emerge as a new class of targetable entities, boosting the quest for novel therapeutic strategies.

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