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J Diabetes Complications. 2010 Mar-Apr;24(2):115-20. doi: 10.1016/j.jdiacomp.2009.01.007. Epub 2009 Mar 6.

Association of genetic variants in the adiponectin encoding gene (ADIPOQ) with type 2 diabetes in Japanese Brazilians.

Author information

1
Division of Endocrinology, Department of Medicine, Federal University of São Paulo, São Paulo, SP, Brazil.

Abstract

AIM:

The objective of this study is to assess the contribution of ADIPOQ variants to type 2 diabetes in Japanese Brazilians.

METHODS:

We genotyped 200 patients with diabetes mellitus (100 male and 100 female, aged 55.0 years [47.5-64.0 years]) and 200 control subjects with normal glucose tolerant (NGT) (72 male and 128 female, aged 52.0 years [43.5-64.5 years]).

RESULTS:

Whereas each polymorphism studied (T45G, G276T, and A349G) was not significantly associated with type 2 diabetes mellitus, the haplotype GGA was overrepresented in our diabetic population (9.3% against 3.1% in NGT individuals, P=.0003). Also, this haplotype was associated with decreased levels of adiponectin. We also identified three mutations in exon 3: I164T, R221S, and H241P, but, owing to the low frequencies of them, associations with type 2 diabetes could not be evaluated. The subjects carrying the R221S mutation had plasma adiponectin levels lower than those without the mutation (2.10 microg/ml [1.35-2.55 microg/ml] vs. 6.68 microg/ml [3.90-11.23 microg/ml], P=.015). Similarly, the I164T mutation carriers had mean plasma adiponectin levels lower than those noncarriers (3.73 microg/ml [3.10-4.35 microg/ml] vs. 6.68 microg/ml [3.90-11.23 microg/ml]), but this difference was not significant (P=.17).

CONCLUSIONS:

We identified in the ADIPOQ gene a risk haplotype for type 2 diabetes in the Japanese Brazilian population.

PMID:
19269196
DOI:
10.1016/j.jdiacomp.2009.01.007
[Indexed for MEDLINE]

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