Format

Send to

Choose Destination
See comment in PubMed Commons below
Cancer Lett. 2009 Aug 8;280(2):222-32. doi: 10.1016/j.canlet.2009.01.040. Epub 2009 Mar 5.

Histone deacetylase inhibitors that target tubulin.

Author information

1
Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universit├Ąt Freiburg, Freiburg, Germany.

Abstract

Epigenetics is defined as heritable changes in gene expression that occur without changes in DNA sequence. Major mechanisms of epigenetics are post-translational histone modifications such as reversible acetylation. Histone deacetylases (HDACs) maintain the acetylation level of histones but also act on non-histone substrates that are involved in signal transduction or cellular transport processes. One important non-histone substrate is tubulin. The isotypes responsible for tubulin deacetylation are HDAC6 and the NAD(+)-dependent histone deacetylase (sirtuin) Sirt2. Here we review the action of those enzymes on tubulin and present an overview over existing inhibitors with a focus on their structural interaction with the targets.

PMID:
19268440
DOI:
10.1016/j.canlet.2009.01.040
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center