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Biochim Biophys Acta. 2009 May;1787(5):335-44. doi: 10.1016/j.bbabio.2009.02.021. Epub 2009 Mar 4.

Mitochondria, calcium and cell death: a deadly triad in neurodegeneration.

Author information

1
Department of Experimental and Diagnostic Medicine, Interdisciplinary Center for the Study of Inflammation, Italy.

Abstract

Mitochondrial Ca(2+) accumulation is a tightly controlled process, in turn regulating functions as diverse as aerobic metabolism and induction of cell death. The link between Ca(2+) (dys)regulation, mitochondria and cellular derangement is particularly evident in neurodegenerative disorders, in which genetic models and environmental factors allowed to identify common traits in the pathogenic routes. We will here summarize: i) the current view of mechanisms and functions of mitochondrial Ca(2+) homeostasis, ii) the basic principles of organelle Ca(2+) transport, iii) the role of Ca(2+) in neuronal cell death, and iv) the new information on the pathogenesis of Alzheimer's, Huntington's and Parkinson's diseases, highlighting the role of Ca(2+) and mitochondria.

PMID:
19268425
PMCID:
PMC2696196
DOI:
10.1016/j.bbabio.2009.02.021
[Indexed for MEDLINE]
Free PMC Article

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