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Diabetes Metab Res Rev. 2009 May;25(4):325-8. doi: 10.1002/dmrr.943.

C-peptide in the natural history of type 1 diabetes.

Author information

1
Department of Medicine, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, WA, USA. jpp@u.washington.edu

Abstract

Type 1 diabetes is diagnosed when the patient's endogenous insulin secretion decreases to a level which results in hyperglycemia. After diagnosis, insulin secretion continues to decline. As a reference for clinical trials trying to preserve endogenous beta-cell function in patients with recently diagnosed type 1 diabetes, in this short review I attempt to summarize the natural history of endogenous beta-cell function after the diagnosis of type 1 diabetes.

PMID:
19267337
PMCID:
PMC2895504
DOI:
10.1002/dmrr.943
[Indexed for MEDLINE]
Free PMC Article

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