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Eur J Immunol. 2009 Apr;39(4):1066-77. doi: 10.1002/eji.200838773.

IL-10 interferes directly with TCR-induced IFN-gamma but not IL-17 production in memory T cells.

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1
Institute of Medical Immunology, Charité, Humboldt-University, Berlin, Germany.

Erratum in

  • Eur J Immunol. 2009 May;39(5):1435.

Abstract

IL-10 is a potent immunoregulatory and anti-inflammatory cytokine. However, therapeutic trials in chronic inflammation have been largely disappointing. It is well established that IL-10 can inhibit Th1 and Th2 cytokine production via indirect effects on APC. Less data are available about the influence of IL-10 on IL-17 production, a cytokine which has been recently linked to chronic inflammation. Furthermore, there are only few reports about a direct effect of IL-10 on T cells. We demonstrate here that IL-10 can directly interfere with TCR-induced IFN-gamma production in freshly isolated memory T cells in the absence of APC. This effect was independent of the previously described effects of IL-10 on T cells, namely inhibition of IL-2 production and inhibition of CD28 signaling. In contrast, IL-10 did not affect anti-CD3/anti-CD28-induced IL-17 production from memory T cells even in the presence of APC. This might have implications for the interpretation of therapeutic trials in patients with chronic inflammation where Th17 cells contribute to pathogenesis.

PMID:
19266486
DOI:
10.1002/eji.200838773
[Indexed for MEDLINE]
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