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Cell Stem Cell. 2009 Mar 6;4(3):191-2. doi: 10.1016/j.stem.2009.02.004.

The side story of stem-like glioma cells.

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1
Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA. anders.persson@ucsf.edu

Abstract

In this issue of Cell Stem Stell, Bleau et al. report that activity of the drug transporter ABCG2 defines a tumorigenic stem-like side population (SP) isolated from glioma. Surprisingly, temozolomide, the first-line chemotherapeutic used for treatment of glioma, increased this side population, and even more so when PTEN was deleted.

PMID:
19265652
DOI:
10.1016/j.stem.2009.02.004
[Indexed for MEDLINE]
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