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Science. 2009 Apr 10;324(5924):258-61. doi: 10.1126/science.1171400. Epub 2009 Mar 5.

Leucine-rich repeat protein complex activates mosquito complement in defense against Plasmodium parasites.

Author information

1
Division of Cell and Molecular Biology, Department of Life Sciences, Imperial College London, Exhibition Road, London SW7 2AZ, UK.

Abstract

Leucine-rich repeat-containing proteins are central to host defense in plants and animals. We show that in the mosquito Anopheles gambiae, two such proteins that antagonize malaria parasite infections, LRIM1 and APL1C, circulate in the hemolymph as a high-molecular-weight complex held together by disulfide bridges. The complex interacts with the complement C3-like protein, TEP1, promoting its cleavage or stabilization and its subsequent localization on the surface of midgut-invading Plasmodium berghei parasites, targeting them for destruction. LRIM1 and APL1C are members of a protein family with orthologs in other disease vector mosquitoes and appear to be important effectors in innate mosquito defenses against human pathogens.

PMID:
19264986
PMCID:
PMC2790318
DOI:
10.1126/science.1171400
[Indexed for MEDLINE]
Free PMC Article
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