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Curr Opin Microbiol. 2009 Apr;12(2):199-204. doi: 10.1016/j.mib.2009.01.004. Epub 2009 Mar 4.

Control of Salmonella pathogenicity island-2 gene expression.

Author information

1
Department of Molecular Microbiology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110, USA. fass@borcim.wustl.edu

Abstract

The Salmonella Pathogenicity Island-2 (i.e. SPI-2) encodes a unique type III secretion system that delivers effector proteins from the Salmonella-containing vacuole (SCV) into the host cell. The SPI-2 locus also encodes translocated effectors as well as a two-component system - termed SpiR/SsrB - that is essential for the expression of SPI-2 genes. Transcription of the horizontally acquired SPI-2 genes requires the ancestral nucleoid-associated proteins (i.e. NAPs) IHF and Fis, the regulatory protein SlyA, and the two-component systems PhoP/PhoQ and OmpR/EnvZ, as well as the DNA binding protein HilD encoded in a different pathogenicity island. Some of these positive SPI-2 regulators act to antagonize the robust silencing promoted by the NAPs H-NS, Hha, and YdgT.

PMID:
19264535
PMCID:
PMC2805070
DOI:
10.1016/j.mib.2009.01.004
[Indexed for MEDLINE]
Free PMC Article

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