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Bioinformatics. 2009 May 1;25(9):1185-6. doi: 10.1093/bioinformatics/btp121. Epub 2009 Mar 4.

A web server for inferring the human N-acetyltransferase-2 (NAT2) enzymatic phenotype from NAT2 genotype.

Author information

1
Gen*NY*Sis Center for Excellence in Cancer Genomics, Department of Epidemiology and Biostatistics, University at Albany, One Discovery Drive, Rensselaer, NY 12144, USA. ikuznetsov@albany.edu

Abstract

N-acetyltransferase-2 (NAT2) is an important enzyme that catalyzes the acetylation of aromatic and heterocyclic amine carcinogens. Individuals in human populations are divided into three NAT2 acetylator phenotypes: slow, rapid and intermediate. NAT2PRED is a web server that implements a supervised pattern recognition method to infer NAT2 phenotype from SNPs found in NAT2 gene positions 282, 341, 481, 590, 803 and 857. The web server can be used for a fast determination of NAT2 phenotypes in genetic screens.

AVAILABILITY:

Freely available at http://nat2pred.rit.albany.edu.

SUPPLEMENTARY INFORMATION:

Supplementary data are available at Bioinformatics online.

PMID:
19261719
PMCID:
PMC2672629
DOI:
10.1093/bioinformatics/btp121
[Indexed for MEDLINE]
Free PMC Article

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