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Bioinformatics. 2009 May 1;25(9):1211-3. doi: 10.1093/bioinformatics/btp124. Epub 2009 Mar 4.

SpliceAid: a database of experimental RNA target motifs bound by splicing proteins in humans.

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  • 1Institute of Biology and Genetics, Polytechnic University of Marche, 60131, Ancona, Italy.


The correct post-transcriptional RNA processing is finely regulated by RNA-binding proteins. Unfortunately, there is little experimental information on target RNA sequences of RNA-binding proteins and moreover such experimentally derived target sequences are annotated in a compact form by the score matrices that overestimate the number of possible recognized sequences. We carried out an exhaustive hand curated literature search to create a database, SpliceAid, collecting all the experimentally assessed target RNA sequences that are bound by splicing proteins in humans. We built a web resource, database driven, to easy query SpliceAid and give back the results by an accurate and dynamic graphic representation.


SpliceAid database is freely accessible at

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