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FEMS Microbiol Lett. 2009 Apr;293(2):292-7. doi: 10.1111/j.1574-6968.2009.01535.x. Epub 2009 Mar 2.

Selective binding of virulence type III export chaperones by FliJ escort orthologues InvI and YscO.

Author information

1
Department of Pathology, Cambridge University, Cambridge, UK. le227@cam.ac.uk

Abstract

Bacteria secrete flagella subunits and deliver virulence effectors via type III export systems. During flagellar filament assembly, a chaperone escort mechanism has been proposed to enhance the export of early, minor flagellar filament components by selectively binding and cycling their chaperones. Here we identify virulence orthologues of the flagellar chaperone escort FliJ and show that the orthologues Salmonella InvI and Yersinia YscO are, like FliJ, essential for their type III export pathway and similarly, do not bind export substrates. Like FliJ, they recognize a subset of export chaperones, in particular those of the host membrane translocon components required for subsequent effector delivery.

PMID:
19260965
PMCID:
PMC3500872
DOI:
10.1111/j.1574-6968.2009.01535.x
[Indexed for MEDLINE]
Free PMC Article

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