Format

Send to

Choose Destination
Ann Neurol. 2009 Feb;65(2):226-9. doi: 10.1002/ana.21508.

Free radical damage to cerebral cortex in Alzheimer's disease, microvascular brain injury, and smoking.

Author information

1
Department of Pathology, University of Washington, Seattle, USA. jsonnen@u.washington.edu

Abstract

Evidence supports a pathogenic role for free radical injury to brain in Alzheimer's disease; however, clinical trial results are only mildly encouraging. Examining brains from The Adult Changes in Thought study offers a unique perspective. Selectively increased free radical damage to cerebral cortex was associated with Alzheimer's disease, microvascular brain injury, and current smoking, but not with antioxidant supplement usage. Our results support suppression of free radical injury to brain as a therapeutic target for Alzheimer's disease and microvascular brain injury; however, future clinical trials should consider other antioxidants or doses than those identified in our study.

PMID:
19259965
PMCID:
PMC2729331
DOI:
10.1002/ana.21508
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center