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Yonsei Med J. 2009 Feb 28;50(1):132-6. doi: 10.3349/ymj.2009.50.1.132. Epub 2008 Feb 24.

Polymorphism of haptoglobin in patients with premature rupture of membrane.

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1
Department of Natural Sciences, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Abstract

PURPOSE:

To investigate whether allelic polymorphism of haptoglobin (Hp) is associated with premature rupture of membrane (PROM), the Hp phenotypes of pregnant women with PROM were analyzed.

PATIENTS AND METHODS:

The Hp phenotypes of 221 pregnant Korean women (187 control and 34 PROM patients) were determined by benzidine/hydrogen peroxide staining, following native polyacrylamide gel electrophoresis of hemoglobin-mixed sera. The Hp allele frequencies were calculated from the data of Hp phenotypes, and overall association with PROM was evaluated using Pearson Chi-Square test.

RESULTS:

The polymorphic distribution of the patients cohort who underwent a normal delivery (control group) was similar to that of healthy Koreans. In contrast, however, patients with PROM showed significantly higher occurrence of the Hp 1-1 phenotype than control group (23.5% vs 8.0%). Hp 2-2 phenotype was lower in PROM cohort (38.2%) than in the control group (48.7%). The Hp(1) allele frequency in PROM group was significantly higher than that in the control group (0.426 vs 0.297, p = 0.034) with odds ratio of 1.762 (95% CI: 1.038 - 2.991).

CONCLUSION:

These findings suggest that pregnant Korean women who possess Hp(1) allele (expressed as Hp 1-1 phenotype) have higher incidence of PROM than women with Hp(2) allele (expressed as Hp 2-2 phenotype). This is the first study that evaluated the significance of Hp polymorphism with respect to the development of PROM.

KEYWORDS:

Haptoglobin; genetic polymorphism; phenotype; premature rupture of membrane (pregnancy)

PMID:
19259359
PMCID:
PMC2649866
DOI:
10.3349/ymj.2009.50.1.132
[Indexed for MEDLINE]
Free PMC Article
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