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South Med J. 1991 Oct;84(10):1205-9.

Benign and malignant neoplasms in a family with Peutz-Jeghers syndrome: study of three generations.

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  • 1School of Primary Medical Care, University of Alabama, Huntsville.


Three members of a family with Peutz-Jeghers syndrome had intussusception due to intestinal hamartomas. In addition, the grandfather had carcinoma of the jejunum, and the granddaughter had benign ovarian sex cord/stromal tumor causing sexual precocity. Benign and malignant tumors, not often associated with Peutz-Jeghers syndrome, pose a further threat in addition to the gastrointestinal bleeding and obstruction that often complicate this inherited syndrome.

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