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Mol Psychiatry. 2009 Oct;14(10):959-67. doi: 10.1038/mp.2009.15. Epub 2009 Mar 3.

Adult hippocampal neurogenesis is involved in anxiety-related behaviors.

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1
INSERM U862, Neurocenter Magendie, Pathophysiology of Addiction group, Bordeaux, France.

Abstract

Adult hippocampal neurogenesis is a unique example of structural plasticity, the functional role of which has been a matter of intense debate. New transgenic models have recently shown that neurogenesis participates in hippocampus-mediated learning. Here, we show that transgenic animals, in which adult hippocampal neurogenesis has been specifically impaired, exhibit a striking increase in anxiety-related behaviors. Our results indicate that neurogenesis plays an important role in the regulation of affective states and could be the target of new treatments for anxiety disorders.

PMID:
19255582
DOI:
10.1038/mp.2009.15
[Indexed for MEDLINE]
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