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Am J Obstet Gynecol. 2009 Mar;200(3):329.e1-8. doi: 10.1016/j.ajog.2008.12.052.

Changes in weight, total fat, percent body fat, and central-to-peripheral fat ratio associated with injectable and oral contraceptive use.

Author information

1
Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, TX . 77555-0587, USA. abberens@utmb.edu

Abstract

OBJECTIVE:

The purpose of this study was to determine changes in bodyweight and composition that result from hormonal contraception.

STUDY DESIGN:

Dual-energy x-ray absorptiometry was performed at baseline and every 6 months for 3 years for 703 women (African American, 200; white, 247; Hispanic, 256) who were beginning the use of oral contraception (OC; n = 245), depot medroxyprogesterone acetate (DMPA; n = 240), or nonhormonal contraception (NH; n = 218). DMPA discontinuers were observed for up to 2 years to examine the reversibility of the observed changes.

RESULTS:

Over 36 months, DMPA users increased their weight (+5.1 kg), body fat (+4.1 kg), percent body fat (+3.4%), and central-to-peripheral fat ratio (+0.1) more than OC and NH users (P < .01). OC use did not cause weight gain. After DMPA discontinuation, NH users lost 0.42 kg in 6 months; OC users gained 0.43 kg in 6 months.

CONCLUSION:

Bodyweight and fat significantly increase with the use of DMPA. After discontinuation of DMPA, some decrease in bodyweight and fat occurs when NH is used.

PMID:
19254592
PMCID:
PMC2853746
DOI:
10.1016/j.ajog.2008.12.052
[Indexed for MEDLINE]
Free PMC Article

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