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Cell Metab. 2009 Mar;9(3):211-2. doi: 10.1016/j.cmet.2009.02.004.

Iron sensing as a partnership: HFE and transferrin receptor 2.

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1
Saint Louis University School of Medicine, St. Louis, MO 63104, USA. flemingr@slu.edu

Abstract

The mechanism by which HFE participates in the regulation of iron homeostasis has remained enigmatic. Gao et al. (2009) make the key discovery that the regulation of hepcidin in response to holotransferrin requires the interaction between HFE and transferrin receptor 2 (TfR2).

PMID:
19254564
DOI:
10.1016/j.cmet.2009.02.004
[Indexed for MEDLINE]
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