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Nepal Med Coll J. 2008 Sep;10(3):176-9.

Controlled programmed trial of Ocimum sanctum leaf on generalized anxiety disorders.

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  • 1Department of Pharmacology, Dr. B.C. Roy Institute of Post Graduate Medical Education and Research, 244B, Acharya J.C. Bose Road, Kolkata 700020, India. surtapas_2007@rediffmail.com

Abstract

Ocimumn sanctum, an Indian medicinal plant, has been on trial for its role in generalized anxiety disorder (GAD) in hospital based clinical set-up. Hamilton's brief psychiatric rating scale (BPRS) and thorough clinical investigations were used to screen the subjects. Thirty-five subjects (21 male and 14 female; average age 38.4 years) were medicated with the plant extract in a fixed dose regime (500 mg/capsule, twice daily, p.o. after meal). They were thoroughly investigated clinically and using standard questionnaires based on different psychological rating scale at baseline (day 0), mid-term (day 30) and final (day 60). The observations exhibited that, O. sanctum significantly (p<0.001) attenuated generalized anxiety disorders and also attenuated its correlated stress and depression. It further significantly (p<0.001) improved the willingness to adjustment and attention in human. Therefore, it may be concluded that O. sanctum may be useful in the treatment of GAD in human and may be a promising anxiolytic agent in near future.

PMID:
19253862
[PubMed - indexed for MEDLINE]
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