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Rev Infect Dis. 1991 Jul-Aug;13 Suppl 8:S691-5.

Pharmacology of bismuth-containing compounds.

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Department of Medicine, Prince Henry's Hospital, Melbourne, Victoria, Australia.


Bismuth compounds have been used for more than two centuries. A review of the modes of action, pharmacokinetics, and toxicity of two commonly used compounds, colloidal bismuth subcitrate and bismuth subsalicylate, is presented. In humans bismuth toxicity is unlikely when therapeutic doses of these compounds are administered for the appropriate duration. The recent use of bismuth compounds to eradicate infection with Helicobacter pylori and to prevent travelers' diarrhea has resulted in scientific reevaluation of these agents.

[Indexed for MEDLINE]

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