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Nat Chem Biol. 2009 Apr;5(4):217-9. doi: 10.1038/nchembio.152. Epub 2009 Mar 1.

Inhibition of Wnt signaling by Dishevelled PDZ peptides.

Author information

1
Department of Protein Engineering, Genentech, Inc, South San Francisco, California, USA.

Abstract

Dishevelled proteins are key regulators of Wnt signaling pathways that have been implicated in the progression of human cancers. We found that the binding cleft of the Dishevelled PDZ domain is more flexible than those of canonical PDZ domains and enables recognition of both C-terminal and internal peptides. These peptide ligands inhibit Wnt/beta-catenin signaling in cells, showing that Dishevelled PDZ domains are potential targets for small-molecule cancer therapeutics.

PMID:
19252499
DOI:
10.1038/nchembio.152
[Indexed for MEDLINE]

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