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Mayo Clin Proc. 2009 Mar;84(3):243-7. doi: 10.1016/S0025-6196(11)61141-5.

Patients' attitudes and preferences about participation and recruitment strategies in clinical trials.

Author information

1
Division of General Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA. sood.amit@mayo.edu

Abstract

OBJECTIVE:

To assess attitudes of patients about participation in clinical trials.

PATIENTS AND METHODS:

This is a self-report survey of 400 patients who underwent general medical evaluations between September and November 2006 at a tertiary care academic medical center in Rochester, MN. We measured knowledge of access to clinical trials, attitudes toward participation, recruitment preferences, and beliefs about research integrity.

RESULTS:

Of 485 consecutive patients, 400 (82%) completed the survey. Previous participation in clinical trials was reported by 112 patients (28%). Most were unaware of online information about clinical trials (330 [82%]), were satisfied with their current knowledge (233 [58%]), expected their treating physician to inform them about current trials (304 [76%]), and showed equal interest in participating in conventional or complementary intervention trials (174 [44%]). Of the 400 respondents, 321 (80%) found it appropriate to be contacted by mail and 253 (63%) by telephone regarding study participation. Most patients (364 [91%]) wanted to be informed about research findings or else would not participate in future clinical trials (272 [68%]). The most frequently expected compensation was free parking (234 [58%]). Most thought that their safety (373 [93%]) and privacy (376 [94%]) would be guarded.

CONCLUSION:

Patients are interested in participating in clinical trials but commonly lack adequate information. If patients received more information (through their treating physicians), enrollment might improve. This single-site study has limited generalizability. Future studies involving a diverse group of patients from a broader geographic distribution will help provide more definitive results.

PMID:
19252111
PMCID:
PMC2664601
DOI:
10.1016/S0025-6196(11)61141-5
[Indexed for MEDLINE]
Free PMC Article
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