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Int J Radiat Oncol Biol Phys. 2009 Mar 15;73(4):988-96. doi: 10.1016/j.ijrobp.2008.12.002.

On the path to seeking novel radiosensitizers.

Author information

1
Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.

Abstract

Radiation therapy is a highly effective cancer treatment modality, and extensive investigations have been undertaken over the years to augment its efficacy in the clinic. This review summarizes the current understanding of the biologic bases underpinning many of the clinically used radiosensitizers. In addition, this review illustrates how the advent of innovative, high-throughput technologies with integration of different disciplines could be harnessed for an expeditious discovery process for novel radiosensitizers, providing an exciting future for such pursuits in radiation biology and oncology.

PMID:
19251086
DOI:
10.1016/j.ijrobp.2008.12.002
[Indexed for MEDLINE]

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