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Eur J Cancer. 2009 Jul;45(10):1831-8. doi: 10.1016/j.ejca.2009.01.031. Epub 2009 Feb 26.

Metabolic syndrome and risk of cancer mortality in men.

Author information

1
Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, United States. jaggersj@gwm.sc.edu

Abstract

BACKGROUND:

Metabolic syndrome (MetS) has been linked with an increased risk of developing cancer; however, the association between MetS and cancer mortality remains less clear. Little research has focused on pre-cancer risk factors that may affect the outcome of treatment. The purpose of this study was to examine the association between MetS and all-cancer mortality in men.

METHODS:

The participants included 33,230 men aged 20-88 years who were enrolled in the Aerobics Centre Longitudinal Study and who were free of known cancer at the baseline.

RESULTS:

At baseline 28% of all the participants had MetS. During an average of 14 years follow-up, there were a total of 685 deaths due to cancer. MetS at baseline was associated with a 56% greater age-adjusted risk in cancer mortality.

CONCLUSION:

These data show that MetS is associated with an increased risk of all-cause cancer mortality in men. Based on these findings, it is evident that successful interventions should be identified to attenuate the negative effects of MetS.

PMID:
19250819
PMCID:
PMC2700189
DOI:
10.1016/j.ejca.2009.01.031
[Indexed for MEDLINE]
Free PMC Article

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