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J Cosmet Dermatol. 2009 Mar;8(1):24-6. doi: 10.1111/j.1473-2165.2009.00419.x.

Botulinum toxin cosmetic therapy correlates with a more positive mood.

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School of Psychology, Cardiff University, Cardiff, UK.



It has been suggested that botulinum toxin A (BTX-A) treatment for frown lines can also be used as a treatment for depression. A psychological mechanism for this effect is reviewed in which paralysis of the corrugator (frown) muscles leads to less facial feedback for negative emotions. Consequently, a negative affect is harder to maintain and so the person has a more positive mood.


In order to test this mechanism, the mood of patients who had received BTX-A treatment for glabelar frown lines was measured and compared with patients who had received other cosmetic treatments.


The BTX-A-treated patients showed significantly less negative mood.


The results support the facial feedback view that frowning can make one unhappier. Treatments that prevent frowning correlate with reduced negative mood.

[Indexed for MEDLINE]

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