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Cancer Cell. 2009 Mar 3;15(3):165-6. doi: 10.1016/j.ccr.2009.02.005.

EpCAM: another surface-to-nucleus missile.

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1
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146, USA. graham.carpenter@vanderbilt.edu

Abstract

The epithelial-specific cell adhesion molecule (EpCAM) modulates cell adhesion and proliferation. Its overexpression correlates with tumor cell proliferation, and EpCAM is a therapeutic target. In the February issue of Nature Cell Biology, Maetzel et al. demonstrate that proliferative responses to EpCAM require regulated intramembrane proteolysis and a nucleocytoplasmic intracellular domain fragment.

PMID:
19249674
DOI:
10.1016/j.ccr.2009.02.005
[Indexed for MEDLINE]
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