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Cancer Cell. 2009 Mar 3;15(3):163-4. doi: 10.1016/j.ccr.2009.02.006.

Taking the stress out of melanoma.

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1
Signal Transduction Team, The Institute of Cancer Research, London SW3 6JB, UK.

Abstract

A recent study published in Molecular Cell describes a mechanism whereby oncogenic BRAF inhibits AMPK in melanoma cells. This may explain why cancer cells expressing oncogenic BRAF grow under conditions of metabolic stress and may provide new therapeutic opportunities to treat this life-threatening disease.

PMID:
19249673
DOI:
10.1016/j.ccr.2009.02.006
[Indexed for MEDLINE]
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