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Neuron. 2009 Feb 26;61(4):493-6. doi: 10.1016/j.neuron.2009.02.003.

Moving or stopping mitochondria: Miro as a traffic cop by sensing calcium.

Author information

1
Synaptic Function Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 35, Room 3B203, 35 Convent Drive, Bethesda, MD 20892-3701, USA.

Abstract

Mitochondrial transport in neurons and their spatial distribution among synapses are directly correlated with synaptic activity. One paper in this issue of Neuron (MacAskill et al.) and two papers recently published in Cell (Wang and Schwarz) and PNAS (Saotome et al.) provide compelling evidence that Miro serves as a calcium sensor that controls mitochondrial mobility.

PMID:
19249268
PMCID:
PMC5102254
DOI:
10.1016/j.neuron.2009.02.003
[Indexed for MEDLINE]
Free PMC Article

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