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Bioorg Med Chem Lett. 2009 Apr 1;19(7):2065-9. doi: 10.1016/j.bmcl.2009.01.104. Epub 2009 Feb 5.

Structure-activity relationship studies of curcumin analogues.

Author information

1
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, 338 Parks Hall, 500 West 12th Avenue, Columbus, OH 43210, USA.

Abstract

Two series of curcumin analogues, a total of twenty-four compounds, were synthesized and evaluated. The most potent compound, compound 23, showed potent growth inhibitory activities on both prostate and breast cancer lines with IC(50) values in sub-micromolar range, fifty times more potent than curcumin. Curcumin analogues might be potential anti-tumor agents for breast and prostate cancers.

PMID:
19249204
DOI:
10.1016/j.bmcl.2009.01.104
[Indexed for MEDLINE]

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