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Pharmacol Ther. 2009 May;122(2):83-96. doi: 10.1016/j.pharmthera.2009.01.005. Epub 2009 Feb 25.

The therapeutic potential of novel cannabinoid receptors.

Author information

1
Department of Pharmacology, University of Washington, Seattle, WA 98115-7280, USA.

Abstract

Cannabinoids produce a plethora of biological effects, including the modulation of neuronal activity through the activation of CB(1) receptors and of immune responses through the activation of CB(2) receptors. The selective targeting of either of these two receptor subtypes has clear therapeutic value. Recent evidence indicates that some of the cannabinomimetic effects previously thought to be produced through CB(1) and/or CB(2) receptors, be they on neuronal activity, on the vasculature tone or immune responses, still persist despite the pharmacological blockade or genetic ablation of CB(1) and/or CB(2) receptors. This suggests that additional cannabinoid and cannabinoid-like receptors exist. Here we will review this evidence in the context of their therapeutic value and discuss their true belonging to the endocannabinoid signaling system.

PMID:
19248809
PMCID:
PMC3685492
DOI:
10.1016/j.pharmthera.2009.01.005
[Indexed for MEDLINE]
Free PMC Article
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