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Nat Rev Immunol. 2009 Apr;9(4):287-93. doi: 10.1038/nri2510.

Towards an understanding of the adjuvant action of aluminium.

Author information

1
HHMI, Integrated Department of Immunology, National Jewish Health, University of Colorado Health Science Center, Denver, Colorado 80262, USA. marrackp@njhealth.org

Abstract

The efficacy of vaccines depends on the presence of an adjuvant in conjunction with the antigen. Of these adjuvants, the ones that contain aluminium, which were first discovered empirically in 1926, are currently the most widely used. However, a detailed understanding of their mechanism of action has only started to be revealed. In this Timeline article, we briefly describe the initial discovery of aluminium adjuvants and discuss historically important advances. We also summarize recent progress in the field and discuss their implications and the remaining questions on how these adjuvants work.

PMID:
19247370
PMCID:
PMC3147301
DOI:
10.1038/nri2510
[Indexed for MEDLINE]
Free PMC Article
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