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Digestion. 2009;79(1):44-51. doi: 10.1159/000204465. Epub 2009 Feb 26.

Incidence of small bowel injury induced by low-dose aspirin: a crossover study using capsule endoscopy in healthy volunteers.

Author information

1
Division of Gastroenterology, Yokohama City University School of Medicine, Kanazawa-ku, Yokohama, Japan. t066011b@yokohama-cu.ac.jp

Abstract

BACKGROUND AND AIMS:

Small intestinal toxicity of low-dose aspirin remains unclear. The purpose of this capsule endoscopy study was to assess the incidence of small bowel injury in healthy volunteers treated with short-term low-dose aspirin.

METHODS:

Healthy subjects were randomly assigned to receive low-dose aspirin for 14 days (Aspirin group) or no drugs for 14 days (Control group). The two treatment occasions were separated by a washout period of at least 4 weeks. All subjects underwent capsule endoscopy at the end of each treatment period.

RESULTS:

After 2 weeks of treatment, the percentages of subjects with small bowel pathology were 80% in the Aspirin group compared with 20% in the Control group (p = 0.023). The incidence of small bowel mucosal breaks in the Aspirin group was higher than that in the Control group, although the difference was not significant (30 vs. 0%; p = 0.210).

CONCLUSIONS:

This is the first pilot study using capsule endoscopy to report on the relation between small bowel injury and low-dose aspirin. Among the healthy subjects, the short-term administration of low-dose aspirin was associated with a mild mucosal inflammation of the small bowel.

PMID:
19246922
DOI:
10.1159/000204465
[Indexed for MEDLINE]

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