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Curr Opin Microbiol. 2009 Apr;12(2):145-51. doi: 10.1016/j.mib.2009.01.008. Epub 2009 Feb 24.

Bacterial sensors of oxygen.

Author information

1
University of Sheffield, UK. jeff.green@sheffield.ac.uk

Abstract

The concentration of molecular oxygen (O(2)) began to increase in the Earth's atmosphere approximately two billion years ago. Its presence posed a threat to anaerobes but also offered opportunities for improved energy conservation via aerobic respiration. The ability to sense environmental O(2) thus became, and remains, important for many bacteria, both for protection and switching between anaerobic and aerobic respiration. Utilizing an iron-sulfur cluster as the sensor of O(2) exploits the ability of O(2) to oxidize the iron-sulfur cluster, ultimately resulting in cluster disassembly. When utilizing heme as the sensor, the capacity of O(2) to form a reversible Fe-O(2) bond or alternatively the oxidation of the heme iron atom itself is used to detect O(2) and switch regulators between active and inactive forms.

PMID:
19246238
DOI:
10.1016/j.mib.2009.01.008
[Indexed for MEDLINE]

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