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Brain Res. 2009 Jun 24;1277:12-23. doi: 10.1016/j.brainres.2009.02.028. Epub 2009 Feb 24.

Feathers and fins: non-mammalian models for hair cell regeneration.

Author information

  • 1Department of Biological Structure, University of Washington, WA 98195-7420, USA. brignull@u.washington.edu

Abstract

Death of mechanosensory cells in the inner ear results in two profound disabilities: hearing loss and balance disorders. Although mammals lack the capacity to regenerate hair cells, recent studies in mice and other rodents have offered valuable insight into strategies for stimulating hair cell regeneration in mammals. Investigations of model organisms that retain the ability to form new hair cells after embryogenesis, such as fish and birds, are equally important and have provided clues as to the cellular and molecular mechanisms that may block hair cell regeneration in mammals. Here, we summarize studies on hair cell regeneration in the chicken and the zebrafish, discuss specific advantages of each model, and propose future directions for the use of non-mammalian models in understanding hair cell regeneration.

PMID:
19245801
PMCID:
PMC2700174
DOI:
10.1016/j.brainres.2009.02.028
[PubMed - indexed for MEDLINE]
Free PMC Article
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