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J Clin Invest. 2009 Feb;119(2):246-9.

DAMPs ramp up drug toxicity.

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1
Department of Medicine and Liver Center, UCSF, San Francisco, California, USA. jmaher@medsfgh.ucsf.edu

Abstract

The clinical syndrome of acetaminophen-induced liver injury represents the combined result of drug toxicity and a potent innate immune response that follows drug-induced cell death. In this issue of the JCI, Imaeda and colleagues report that DNA released from dying hepatocytes is a key stimulus of innate immune activation in the acetaminophen-treated mouse liver (see the related article beginning on page 305). They present evidence indicating that hepatocyte DNA promotes immune activation by acting as a danger-associated molecular pattern (DAMP) that stimulates cytokine production in neighboring sinusoidal endothelial cells via Tlr9 and the Nalp3 inflammasome.

PMID:
19244605
PMCID:
PMC2631305
[Indexed for MEDLINE]
Free PMC Article
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