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Methods Mol Biol. 2009;492:295-308. doi: 10.1007/978-1-59745-493-3_18.

Tissue analysis with high-resolution imaging mass spectrometry.

Author information

1
FOM Institute for Atomic and Molecular Physics FOM-AMOLF, Amsterdam, The Netherlands.

Abstract

Molecular mass spectrometric images of tissue sections facilitate precise location of biomolecules, drugs, their metabolites and the biomolecular aberrations they target. Technological developments are rapidly expanding the capabilities of imaging mass spectrometers. Speed, resolution, sensitivity, and sample preparation protocols are no longer limiting factors in its application.

PMID:
19241041
DOI:
10.1007/978-1-59745-493-3_18
[Indexed for MEDLINE]

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