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Chem Commun (Camb). 2009 Mar 14;(10):1216-8. doi: 10.1039/b820879d. Epub 2009 Feb 3.

Iron-catalysed fluoroaromatic coupling reactions under catalytic modulation with 1,2-bis(diphenylphosphino)benzene.

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1
International Research Center for Elements Science (IRCELS), Institute for Chemical Research, Uji, Kyoto 611-0011, Japan.

Abstract

A catalytic amount of 1,2-bis(diphenylphosphino)benzene (DPPBz) achieves selective cleavage of sp(3)-carbon-halogen bond in the iron-catalysed cross-coupling between polyfluorinated arylzinc reagents and alkyl halides, which was unachievable with a stoichiometric modifier such as TMEDA; the selective iron-catalysed fluoroaromatic coupling provides easy and practical access to polyfluorinated aromatic compounds.

PMID:
19240878
DOI:
10.1039/b820879d
[Indexed for MEDLINE]
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