Format

Send to

Choose Destination
See comment in PubMed Commons below
Gut. 2009 Dec;58(12):1680-9. doi: 10.1136/gut.2008.155853. Epub 2009 Feb 24.

Recent advances in autoimmune pancreatitis.

Author information

1
Miles & Shirley Fiterman Center for Digestive Diseases, Mayo Clinic, Rochester, MN 55905, USA.

Erratum in

  • Gut. 2010 Jul;59(7):1007.

Abstract

Autoimmune pancreatitis (AIP) is distinct from calcifying and obstructive forms of chronic pancreatitis. Clinically and histologically it has two distinct subsets: (i) lymphoplasmacytic sclerosing pancreatitis or type 1 AIP which appears to be a systemic disease characterised by abundant infiltration of affected organs with immunoglobulin G4 (IgG4)-positive plasma cells and (2) duct-centric or type 2 AIP characterised by granulocyte epithelial lesions in the pancreas without systemic involvement. In AIP a marked lymphoplasmacytic infiltrate that responds dramatically to steroid therapy suggests an autoimmune aetiology. However, the target autoantigen(s) and the effector cells in AIP remain speculative. Despite the consistent elevation in serum IgG4 levels and tissue infiltration with IgG4-positive plasma cells in type 1 AIP, the role of IgG4 in its pathogenesis remains unknown. Recent development of animal models of AIP will help improve our understanding of the pathogenesis of these newly described forms of chronic pancreatitis.

PMID:
19240063
DOI:
10.1136/gut.2008.155853
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center