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Cell. 2009 Feb 20;136(4):746-62. doi: 10.1016/j.cell.2009.01.036.

Fidelity at the molecular level: lessons from protein synthesis.

Author information

1
Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

The faithful and rapid translation of genetic information into peptide sequences is an indispensable property of the ribosome. The mechanistic understanding of strategies used by the ribosome to achieve both speed and fidelity during translation results from nearly a half century of biochemical and structural studies. Emerging from these studies is the common theme that the ribosome uses local as well as remote conformational switches to govern induced-fit mechanisms that ensure accuracy in codon recognition during both tRNA selection and translation termination.

PMID:
19239893
PMCID:
PMC3691815
DOI:
10.1016/j.cell.2009.01.036
[Indexed for MEDLINE]
Free PMC Article

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