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Clin Rheumatol. 2009 Jun;28(6):739-43. doi: 10.1007/s10067-009-1143-x. Epub 2009 Feb 24.

Postpartum Churg-Strauss syndrome with severe cardiac involvement: description of a case and review of the literature.

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Department of Pathology and Laboratory Medicine, Section of Pathology, University of Parma, Via Gramsci 14, 43100, Parma, Italy.


Churg-Strauss syndrome (CSS) is a rare small- or intermediate-vessel necrotizing vasculitis typically characterized by asthma, lung infiltrates, necrotizing granulomas, and hypereosinophilia. In this report, we describe the case of a 35-year-old woman who, during her third trimester of pregnancy, developed dyspnea and, after delivery, severe cardiac failure which required heart transplantation. Diagnosis of CSS was made after performing a myocardial biopsy. We have also undertaken a review of the English-language literature regarding previously reported cases of pregnancies in women suffering from Churg-Strauss syndrome with particular attention to those patients with cardiovascular involvement.

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