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Bioinformation. 2008;3(3):137-8. Epub 2008 Nov 9.

ESBRI: a web server for evaluating salt bridges in proteins.

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Laboratory of Bioinformatics and Computational Biology, Institute of Food Science, CNR, via Roma 52 A/C, 83100 Avellino, Italy.


Salt bridges can play important roles in protein structure and function and have stabilizing and destabilizing effects in protein folding. ESBRI is a software available as web tool which analyses the salt bridges in a protein structure, starting from the atomic coordinates. In the case of protein complexes, the salt bridges between protein chains can be evaluated, as well as those among specific charged amino acids and the different protein subunits, in order to obtain useful information regard the protein-protein interaction.


The service is available at the URL:


peptides; protein-protein interaction; proteins; salt bridges; web-software

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