Format

Send to

Choose Destination
Semin Immunol. 2009 Jun;21(3):156-63. doi: 10.1016/j.smim.2009.01.001. Epub 2009 Feb 23.

Endoplasmic reticulum stress in the intestinal epithelium and inflammatory bowel disease.

Author information

1
Department of Medicine II (Gastroenterology and Hepatology), Innsbruck Medical University, Innsbruck, Austria.

Abstract

The unfolded protein response as a consequence of endoplasmic reticulum (ER) stress has recently been implicated as a novel mechanism that may lead to inflammatory bowel disease (IBD). Impairment of proper ER stress resolution in highly secretory Paneth and, to a lesser extent, goblet cells within the epithelium can primarily lead to intestinal inflammation. An inability to manage ER stress may not only be a primary originator of intestinal inflammation as exemplified by genetic polymorphisms in XBP1 that are associated with IBD but also a perpetuator of inflammation when ER stress is induced secondarily to inflammatory mediators or microbial factors. Furthermore, ER stress pathways may interact with other processes that lead to IBD, notably autophagy.

PMID:
19237300
PMCID:
PMC4736746
DOI:
10.1016/j.smim.2009.01.001
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center